Royal Air Force Typhoon fighter aircraft have joined forces with French aircraft in a combined operation on an underground arms cache in Syrian territory used by the IS group, per a report from the UK's MoD.
The site, located using intelligence, was assessed as housing weapons and explosive materials, the statement said, and was located in hills just to the north of the ancient city of Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to strike a series of approach shafts leading to the site... early reports suggest the strike was effective," officials stated.
There was no indication of any harm to civilians in the strike on Saturday evening and each participating jet returned to base without incident, the defence officials confirmed.
The British jets were supported by a Voyager refuelling tanker.
IS - also known as the so-called Islamic State - imposed extremist governance over significant areas in Syria and Iraq prior to its 2019 collapse.
"This action demonstrates British leadership, and resolve to work closely with our partners, to eliminate any re-emergence of IS and their dangerous and violent ideologies in the region," Britain's Defence Chief the Defence Secretary stated.
British military aircraft have carried out surveillance missions over Syria to "forestall any efforts to regroup" of Islamic State after its routing at the Baghuz confrontation in 2019, the authorities noted.
"I must thank the personnel of the UK armed forces who took part in this mission for their professionalism and their bravery," Healey said. "Including them were thousands of British troops deployed over the festive period. This mission, to remove militants who pose a risk to our security, demonstrates how British military are prepared to act, all year round, keeping Britain secure within its borders and strong abroad."
During December, the US military conducted what it described as a "large-scale strike" against Daesh sites in the country, after an ambush resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The United Nations says Daesh still maintains between 5,000 and 7,000 militants in Iraq and Syria.